In order to study an immunopathological mechanism in lichenoid drug eruption, an immunofluorescence and an immunoperoxidase techniques were performed using monoclonal antibodies on frozen tissue sections from 4 patients. OKT4-positive cells (helper/inducer T cells, DTH T cells) were major components of infiltrating cells in the dermis and were detected at the dermo-epidermal junction (D-E junction). OKT8-positive cells (suppressor/killer T cells) could also be identified in the epidermis and D-E junction. Increased numbers of OKT6-positive cells (Langerhans cells) were seen in the epidermis and dermis, OKIa1, a monoclonal antibody reactive with human HLA-DR antigens, showed positive labelling of keratinocytes and dermal infiltrates. Furthermore, there were some anti-IL-2 receptor-positive cells in the dermal infiltrates. These findings suggest that expression of HLA-DR antigens on the keratinocyte membrane and activation of autoreactive T cells may play a significant role in the etiopathogenesis of lichenoid drug eruption.
2) 薬疹,特に扁平苔癬型薬疹における免疫組織学的検索(シンポジウム 「薬剤アレルギーの現状」, 第415回新潟医学会)
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