In Niigata prefecture, we have screened 27,894 infants at the age of 6 months for neuroblastomas using urine-spotted filterpapaer. 1,121 infants (4.0%) were positive for urinary vanyl mandelic acid (VMA), and 94 infants (0.3%) were referred to our hospital for further examination. Various clinical tests including determination of urinary cathecholamines on high-power liquid chromatography, abdominal echography, intravenous pyelography, CT-scanning, bone scintigraphy, and blood chemical analysis were performed, which revealed no abnormal findings in the infant suspected to have neuroblastomas.