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慢性骨髄性白血病におけるインターフェロン-α添加骨髄長期培養によるPh^1陽性クローンの選択的除去と自家骨髄移植への応用
http://hdl.handle.net/10191/34210
http://hdl.handle.net/10191/34210f9fa1f5b-12d4-418f-b3e5-e53ab9fa1b38
名前 / ファイル | ライセンス | アクション |
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104(6)_508-517.pdf (2.3 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-11-11 | |||||
タイトル | ||||||
タイトル | 慢性骨髄性白血病におけるインターフェロン-α添加骨髄長期培養によるPh^1陽性クローンの選択的除去と自家骨髄移植への応用 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 慢性骨髄性白血病におけるインターフェロン-α添加骨髄長期培養によるPh^1陽性クローンの選択的除去と自家骨髄移植への応用 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | autologous bone marrow transplantation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | interferon-α : INF-α | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | long term marrow culture : LTMC | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chronic myelogenous leukemia : CML | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 自家骨髄移植 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | インターフェロン-α | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 骨髄長期培養 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 慢性骨髄性白血病 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Purging of ph^1 Positive Cells in CML by a Combination with Long Term Marrow Culture and Interferon-α and its Application to Autologous Bone Marrow Transplantation | |||||
著者 |
成田, 美和子
× 成田, 美和子 |
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著者別名 | ||||||
識別子 | 134934 | |||||
識別子Scheme | WEKO | |||||
姓名 | Narita, Miwako | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | For the treatment of CML, bone marrow transplantation is thougt to be the only method that consistently restores normal hematopoiesis for long period. However, the indication of allogeneic marrow transplantation is restricted to a small number of patients with CML. As functionally competent Ph^1 negative hematopoietic stem cells are now known to persist in CML, autologous marrow transplantation might be undertaken with curative intent if clonogenic malignant (Ph^1 positive) stem cells could be eliminated from the autograft. For the purpose of developing a effective method to purge Ph^1 positive stem cells, we tried long term CML marrow culture in combination with IFN-α that is clinically established as a drug to inhibit the proliferation of Ph^1 positive cells. The long term culture in the presence of IFN-α (10~10^3 lU/ml) was found to eradicate Ph^1 positive CFU-GM derived colony forming cells in all CML patients in time and dose dependent manner. The effects of IFN-α to the microenvironment and to Ph^1 positive cells are still not so well analysed, but our results suggest that Ph^1 negative CFU-GM are more tolerable than Ph^1 positive ones in long term culture system with IFN-α. Thus, this culture system might be useful method to purging malignant (Ph^1 positive) clone for autologous marrow transplantation in patients with CML. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 104, 号 6, p. 508-517, 発行日 1990-06 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |