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インスリン様増殖因子(IGF)-IIの組織分布の特異性とそのin vitro活性
http://hdl.handle.net/10191/34208
http://hdl.handle.net/10191/342085200bffa-15ae-4f25-b595-a44d87f335ff
名前 / ファイル | ライセンス | アクション |
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104(6)_447-453.pdf (2.5 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-11-11 | |||||
タイトル | ||||||
タイトル | インスリン様増殖因子(IGF)-IIの組織分布の特異性とそのin vitro活性 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | インスリン様増殖因子(IGF)-IIの組織分布の特異性とそのin vitro活性 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IGF-II | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | paraganglionic cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | paraganglioma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nerve growth factor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | インスリン様増殖因子-II | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 旁神経節 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 旁神経節腫 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 神経成長因子 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Selective Localization of Insulin-like Growth factor (IGF)-II Immunoreactivity in human tissues and in vitro activity of IGF-II | |||||
著者 |
鈴木, 利光
× 鈴木, 利光 |
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著者別名 | ||||||
識別子 | 134884 | |||||
識別子Scheme | WEKO | |||||
姓名 | Suzuki, Toshimitsu | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Insulin-like growth factor (IGF)-II immunoreactivity in human tissues was detected with use of monoclonal antibody against rat IGF-II, which crossreacts to human IGF-II. The results indicated that IGF-II immunoreactivity localized selectively in normal paraganglionic cells including carotid body, adrenal medulla and retroperitoneal paraganglion. In addition, fetal kidney of 14th gestational week revealed IGF-II immunoreactivity in limited proximal convolution to its beginning segment. Other tissues were regularly negative for the immunoreactivity. All of 29 tumors originated from this paraganglionic system harbored IGF-II immunoreactive tumor cells with high frequency, although one tumor of glomus jugulare in origin failed to immunolabelling. IGF-II induced morphological differentiation of rat pheochromocytoma cell line PC 12 and also enhanced cell growth of human neuroblastoma cell line NB-45-nu F in vitro, as potent as nerve growth factor which caused same effects on these two cell lines. From these results, IGF-II might be a kind of nerve growth factor of human paraganglionic system. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 104, 号 6, p. 447-453, 発行日 1990-06 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |