The agent that causes blood-borne non-A, non-B hepatitis has been identified by M.Houghton and his colleagues. A cDNA of this virus has been cloned and assay system of HCV-antibody has been established. By using this assay system, we have been accumulating new epidemiological and clinical findings. We also isolated HCVcDNA clones from the serum of a Japanese healthy HCV carrier. Nucleotide sequences of these cDNA clones showed high homology with the Houghton's clones. Amino acid homology in the non-structural region (NS3) is 93% between the two HCV isolates.
4) C型肝炎ウイルスをめぐって(シンポジウム 輸血をめぐる諸問題 : とくに輸血後肝炎防止について, 第456回新潟医学会)
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