WEKO3
アイテム
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サルコイドーシスにおける肺胞マクロファージIL-1β, TNF-αおよび肺胞リンパ球IFN-γの産生
http://hdl.handle.net/10191/37895
http://hdl.handle.net/10191/3789582c4d0d1-b020-4336-a7f0-c298751ac65d
名前 / ファイル | ライセンス | アクション |
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108(1)_32-39.pdf (1.2 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-02-08 | |||||
タイトル | ||||||
タイトル | サルコイドーシスにおける肺胞マクロファージIL-1β, TNF-αおよび肺胞リンパ球IFN-γの産生 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | サルコイドーシスにおける肺胞マクロファージIL-1β, TNF-αおよび肺胞リンパ球IFN-γの産生 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | sarcoidosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bronchoalveolar lavage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | interleukin-1β | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | umor necrosis factor-α | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | interferon-γ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | サルコイドーシス | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 気管支肺胞洗浄 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-1β | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TNF-α | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IFN-γ | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Production of IL-1β, TNF-α and IFN-γ from Alveolar Cells in Patients with Sarcoidesis | |||||
著者 |
平原, 克己
× 平原, 克己 |
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著者別名 | ||||||
識別子 | 121690 | |||||
識別子Scheme | WEKO | |||||
姓名 | Hirahara, Katsumi | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We studied the production of IL-1β, TNF-α and IFN-γ by alveolar cells obtained by bronchoalveolar lavage (BAL) in patients with sarcoidosis. The culture supernatant of alveolar macrophages (AMs) and peripheral blood monocytes (PB-Mo) of patients with sarcoidosis and control subjects were assayed for IL-1β and TNF-α using ELISA system. IFN-γ was also measured in the culture supernatants of BAL-lymphocytes (BAL-Ly) and peripheral blood lymphocytes (PB-Ly) by RIA system. In patients with sarcoidosis, the production of IL-1β was significantly higher in both LPS-stimulated AMs and PB-Mo than untreated AMs and PB-Mo. The content of TNF-α was significantly higher in the supernatant from lipopolysaccharide (LPS) stimulated AMs than that from untreated AMs. However, there was no significant difference in TNF-α content of the supernatant between LPS-stimulated and untreated PB-Mo. Concerning IFN-γ, the culture supernatant from both phytohemagglutinin stimulated BAL-Ly and PB-Ly contained more IFN-γ than in untreated BAL-Ly and PB-ly. This study demonstrated that AMs from patients with sarcoidosis increased the production of TNF-α and that this increase was compartmentalized to the lungs, since there was significant difference in TNF-α production between LPS-stimulated AMs and PB-Mo. It is suggested that acceleratod TNF-α release by AMs play a role in immune effector cells activation in the pulmonary sarcoidosis lesions. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 108, 号 1, p. 32-39, 発行日 1994-01 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |