The OLETF rat is a well-established model for the study of type 2 diabetes associated with obesity and has been shown to possess multiple hyperglycemic alleles in its genome. Here we focused on and carefully characterized one of the previously reported congenic strains, F.O-Nidd3/of that carries the OLETF allele of the Nidd3/of locus (also known as Niddm21 in the Rat Genome Database) in the normoglycemic F344 genetic background. A prominent finding was that the F1 progeny between the congenic and the F344 stain, whose genotype is heterozygote at the Nidd3/of locus, showed mild hyperglycemia equal to the parental congenic rat, suggesting that the OLETF allele is dominant. To our knowledge, this is the first study in which a diabetic QTL has been directly demonstrated to be dominant by using congenic strains.
雑誌名
Experimental animals
巻
57
号
2
ページ
135 - 138
発行年
2008-12
出版者
Japanese Association for Laboratory Animal Science
ISSN
13411357
書誌レコードID
AA11032321
DOI
info:doi/10.1538/expanim.57.135
権利
Copyright(C)2008 Japanese Association for Laboratory Animal Science
本文データは学協会の許諾に基づきJ-Stageから複製したものである
An OLETF Allele of Hyperglycemic QTL Nidd3/of Is Dominant
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