The condition of hyperglycemia results from multiple genetic and environmental factors. In recent years much progress has been made with regards to the search for candidate genes involved in the expression of various common diseases including type 2 diabetes. However less is known about the specific genetic and environmental connections that are important for the development of the disease. In the present study, we used hyperglycemic congenic rats to address this issue. When given a normal diet, two hyperglycemic QTLs (quantitative trait locus), Nidd2/of and Nidd10/of, showed mild obesity and/or increased blood glucose in the oral glucose tolerance test. In a double congenic strain possessing both loci, these indices were not significantly different from those of either single congenic strain. In contrast, the double congenic strain fed a high-calorie diet showed significantly greater body weight than the single congenic strains or normoglycemic control rats. Although postprandial glucose levels of the double congenic rat were not further aggravated even on the high fat diet, it was notable that the postprandial insulin levels were drastically elevated. From these results, we constructed a novel model animal especially for the study of prediabetic hyperinsulemia, in which two QTLs and an additional dietary condition are involved. This may help to shed light on the genetic basis and gene-to-diet interaction during the early stage of type 2 diabetes.
雑誌名
Experimental animals
巻
60
号
2
ページ
125 - 132
発行年
2011-01
出版者
Japanese Association for Laboratory Animal Science
ISSN
13411357
書誌レコードID
AA11032321
DOI
info:doi/10.1538/expanim.60.125
権利
Copyright(C)2011 Japanese Association for Laboratory Animal Science
本文データは学協会の許諾に基づきJ-Stageから複製したものである
Genetic Interaction between Hyperglycemic QTLs Is Manifested under a High Calorie Diet in OLETF-Derived Congenic Rats
60_2_125-132.pdf
(524.29KB)
学術リポジトリとは