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陽電子放出核種で標識された脂肪酸関連診断薬の開発とその医学利用
http://hdl.handle.net/10191/46471
http://hdl.handle.net/10191/4647174195466-5fe9-455a-8b2b-ca50115c06b6
名前 / ファイル | ライセンス | アクション |
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113(1)_1-13.pdf (1.9 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-02-16 | |||||
タイトル | ||||||
タイトル | 陽電子放出核種で標識された脂肪酸関連診断薬の開発とその医学利用 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 陽電子放出核種で標識された脂肪酸関連診断薬の開発とその医学利用 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | [^<11>C]/[^<18>F]labeled fatty acid derivatives | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PET | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | [^<11>C]HCN | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 5-methyl-17-[^<18>F]fluoroheptadecanoic acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myocardial imaging tracers | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | [^<11>C]/[^<18>F]標識脂肪酸誘導体 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 陽電子断層撮像法 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | [^<11>C]標識シアン化水素 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 5-メチル-17-[^<18>F]フルオロヘプタデカン酸 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 心筋イメージング剤 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Development of Fatty Acid Derivatives Labeled with Short-lived Positron Emitters and Its Application for PET Studies | |||||
著者 |
高橋, 俊博
× 高橋, 俊博 |
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著者別名 | ||||||
識別子 | 103444 | |||||
識別子Scheme | WEKO | |||||
姓名 | Takahashi, Toshihiro | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | For the development of myocardial imaging tracers in PET (positron emission computed tomography) studies, new labeling methods and new radiopharmaceuticals of [^<11>C]/[^<18>F] labeled fatty acid derivatives were investigated. In [^<11>C] labeling of fatty acids, a new chemical approach to the preparation of [1-^<11>C] fatty acids from [^<11>C] HCN was developed. This method has some advantages, such as no requirement of absolutely anhydrous solvent, easy [^<11>C] labeling using an extremely small amount of substrate, and good reproducibility. From these advantages, it has been shown that this new approach is one of efficient synthetic methods of [1-^<11>C] labeled fatty acids for use in routine PET studies. While, in [^<18>F] labeling of fatty acids, 5-methyl-17-[^<18>F] fluoroheptadecanoic acid (5-MFHA) was proposed as a new myocardial imaging tracer for PET studies. From accumulation studies and metabolic studies of the heart muscle, 5-MFHA showed some properties, such as the relatively high initial uptake, the longer retention of myocardial accumulation and the quite similar metabolic pattern in the myocardium to that of straight-chain-fatty acids. These properties demonstrate that 5-MFHA is one of the structually modified fluorofatty acids and may be one of available myocardial imaging tracers. According to PET studies, this expectation is well supported. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 113, 号 1, p. 1-13, 発行日 1999-01 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |