WEKO3
アイテム
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Unresectable or metastatic esophageal carcinoma patients do not benefit from the present multimodality treatment regimens in terms of survival. The objectives of this study were to analyze the antibody response to NY-ESO-1 antigen in patients with esophageal cancer and to determine the potential of NY-ESO-1 for use in tumor-specific immunotherapy. METHODS: Serum from 69 patients with esophageal cancer was investigated for antibody production against NY-ESO-1 by Western blot analysis. Also analyzed by immunohistochemistry were 56 tissue samples from these patients for NY-ESO-1 protein expression. RESULTS: NY-ESO-1 protein expression was found in 18 of 56 (32%) esophageal carcinomas. Serum immunoreactivity specific for NY-ESO-1 was found in 9 patients (13%) of whom 8 were in the advanced stage (stages III and IV). There was no relationship between clinicopathologic features and serum immunoreactivity for NY-ESO-1. 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NY-ESO-1 expression and its serum immunoreactivity in esophageal cancer
http://hdl.handle.net/10191/4928
http://hdl.handle.net/10191/492838537403-505b-4443-911b-e79204b501ce
名前 / ファイル | ライセンス | アクション |
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0707062.pdf (766.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-07-09 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | NY-ESO-1 expression and its serum immunoreactivity in esophageal cancer | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Esophageal cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tumor antigens | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | NY-ESO-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Humoral immunity | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Akcakanat, Argun
× Akcakanat, Argun× Kanda, Tatsuo× Koyama, Yu× Watanabe, Michitoshi× Kimura, Eiji× Yoshida, Yutaka× Komukai, Shintarou× Nakagawa, Satoru× Odani, Shoji× Fujii, Hiroshi× Hatakeyama, Katsuyoshi |
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著者別名 | ||||||
識別子 | 4542 | |||||
識別子Scheme | WEKO | |||||
姓名 | 神田, 達夫 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | PURPOSE: NY-ESO-1, a member of the cancer/testis antigen (CTA) family, elicits humoral and cellular immune responses in patients with advanced cancer. Unresectable or metastatic esophageal carcinoma patients do not benefit from the present multimodality treatment regimens in terms of survival. The objectives of this study were to analyze the antibody response to NY-ESO-1 antigen in patients with esophageal cancer and to determine the potential of NY-ESO-1 for use in tumor-specific immunotherapy. METHODS: Serum from 69 patients with esophageal cancer was investigated for antibody production against NY-ESO-1 by Western blot analysis. Also analyzed by immunohistochemistry were 56 tissue samples from these patients for NY-ESO-1 protein expression. RESULTS: NY-ESO-1 protein expression was found in 18 of 56 (32%) esophageal carcinomas. Serum immunoreactivity specific for NY-ESO-1 was found in 9 patients (13%) of whom 8 were in the advanced stage (stages III and IV). There was no relationship between clinicopathologic features and serum immunoreactivity for NY-ESO-1. NY-ESO-1 protein expression was detected in three of five antibody-positive patients whose tissue was available for analysis. Survival analysis showed no significant difference between antibody-positive and antibody-negative patient groups. CONCLUSIONS: A humoral immune response to NY-ESO-1 antigen was established in patients with advanced esophageal cancer. NY-ESO-1 is a good candidate for vaccine-based immunotherapy for advanced esophageal carcinoma. | |||||
書誌情報 |
Cancer Chemotherapy and Pharmacology en : Cancer Chemotherapy and Pharmacology 巻 54, 号 1, p. 95-100, 発行日 2004-07 |
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出版者 | ||||||
出版者 | Springer Verlag | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03445704 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00598397 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 15118836 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1007/s00280-004-0768-3 | |||||
著者版フラグ | ||||||
値 | author |