Comparison of Biological Behavior of Differentiated Type Gastric Adenocarcinoma by Their Cytological Grade of Atypia : From the Aspect of Invasive Capacity and Cell-Proliferative Activity
Differentiated type gastric adenocarcinomas are subclassified into high-grade and low-grade by their cytological atypia. We aimed to clarify the difference in biological behavior (grade of malignancy) of high-grade and low-grade carcinomas in the aspect of invasive capacity and cell-proliferative activity. Forty-six high-grade and fifteen low-grade gastric submucosal carcinomas (well or moderately differentiated) were selected for the study. High-grade carcinoma showed smaller (trend) intramucosal spread while greater (P<0.01) area of submucosal invasion and its proportion to the intramucosal spread than low-grade carcinoma. Cell-proliferative activity was estimated by Ki-67 labeling index. For both intramucosal and submucosal area, high-grade carcinoma showed higher (P<0.01, respectively) Ki-67 labeling index than low-grade carcinoma. These results indicate that high-grade carcinoma has a higher invasive capacity and proliferative activity than low-grade carcinoma and suggesting that high-grade carcinoma is a high-grade malignancy and low-grade carcinoma is a low-grade malignancy.
細胞異型度分類からみた分化型胃癌の生物学的悪性度の検討 : 高・低異型度癌のsm浸潤能と細胞増殖能の比較から
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