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Cardioprotective effects of recombinant human erythropoietin in rats with Experimental autoimmune myocarditis
http://hdl.handle.net/10191/1165
http://hdl.handle.net/10191/11650b715b88-bd90-4aba-9f4a-7a5419f63383
名前 / ファイル | ライセンス | アクション |
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24_0007.pdf (4.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-04-23 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Cardioprotective effects of recombinant human erythropoietin in rats with Experimental autoimmune myocarditis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Erythropoietin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Experimental autoimmune myocarditis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Erythropoietin receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Apoptosis | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Mitsuma, Wataru
× Mitsuma, Wataru× Ito, Masahiro× Kodama, Makoto× Fuse, Koichi× Okamura, Kazuki× Minagawa, Shiro× Kato, Kiminori× Hanawa, Haruo× Toba, Ken× Nakazawa, Mikio× Aizawa, Yoshifusa |
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著者別名 | ||||||
識別子 | 4271 | |||||
識別子Scheme | WEKO | |||||
姓名 | 鳥羽, 健 | |||||
言語 | ja | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Erythropoietin (EPO) has been known to have cytoprotective effects on several types of tissues, presumably through modulation of apoptosis and inflammation. The effect of EPO on myocardial inflammation, however, has not yet been clarified. We investigated the cardioprotective effects of EPO in rats with experimental autoimmune myocarditis (EAM). Seven-week-old Lewis rats immunized with cardiac myosin were treated either with EPO or vehicle and were examined on day22. EPO attenuated the functional and histological severity of EAM along with suppression of mRNAs of tumor necrosis factor (TNF)-a and interleukin (IL)-6 in the hearts as well as a reduction of apoptotic cardiomyocytes. The EPO receptor (EPO-R) was upregulated in the myocardium of EAM compared with that of healthy rats. These results may suggest that EPO ameliorated the progression of EAM by modulating myocardial inflammation and apoptosis. | |||||
言語 | en | |||||
書誌情報 |
en : Biochemical and Biophysical Research Communications 巻 344, 号 3, p. 987-994, 発行日 2006-03 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0006-291X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00564395 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | http://doi.org/10.1016/j.bbrc.2006.03.230 | |||||
権利 | ||||||
権利情報 | Elsevier Inc. | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
著者版フラグ | ||||||
値 | author |