The role of stereotactic radiotherapy has become increasingly important because it has been introduced to treat not only intracranial but also extracranial lesions. The increased accuracy and conformity of radiation treatment has made it possible to apply more and more radical treatment. In this paper, first experience in using the Novalis for various brain, lung and liver tumors were reported. Stereotactic radiotherapy using Novalis shaped beam surgery system are effective and safe noninvasive treatment modalities for various intracranial and extracranial tumors.